Evaluation of IL-6, vitamin D level in chronic periodontitis patients after non-surgical periodontal therapy

Supritha Pai; Nina Shenoy; Deepa Sara John

Supritha Pai Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Periodontics, Mangalore, India.
Nina Shenoy Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Periodontics, Mangalore, India. https://orcid.org/0000-0002-1189-6901
Deepa Sara John Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Periodontics, Mangalore, India.

Keywords: Periodontitis, nutrition, cytokines, Scaling and root planing, vitamin D

Abstract

Background and aims: Vitamin D is hypothesized to prevent periodontal disease progression through immune modulation and regulation of systemic calcium. A multifunctional cytokine, interleukin (IL)-6, mediates tissue injury, infection, and bone resorption in periodontitis. The goal of Phase I therapy is to halt the disease progression. Hence, this study aims at correlating the serum level of Vitamin D and IL-6 in patients with chronic periodontitis before and following periodontal non-surgical therapy.

Material and method: A total of 60 patients were divided into two groups of 30 each, comprising healthy and chronic periodontitis patients, respectively. Clinical parameters were recorded at baseline and post-treatment. Serum samples were analyzed to estimate Vitamin D levels and IL-6 levels

Results: At baseline, the mean serum IL-6 levels were significantly higher in group B (49.13 ± 5.65) and, the serum vitamin D level indicated an insufficiency (20.62 ± 5.76). However, following non-surgical periodontal therapy, the vitamin D level improved (31.76± 8.12) and IL-6 level decreased markedly (40.16± 7.88). In addition, there was an improvement in the clinical parameters.

Conclusions: It can be concluded that there is an association between chronic periodontitis, Vitamin D and IL-6 indicating their potential role as risk indicators for periodontal disease.