Serum Testosterone and Metabolic Syndrome in Old-Aged Males: Preliminary Findings of the AHAP Cohort Study

Reza Ghadimi; Aylar Khalilipour; Nazila Malekian; Haleh Esmaili; Seyed Reza Hosseini; Mohammadali Bayani; Ali Bijani; Fatemeh Izadpanah

Reza Ghadimi Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences,
Aylar Khalilipour Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Nazila Malekian Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Haleh Esmaili Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Seyed Reza Hosseini Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Mohammadali Bayani Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran
Ali Bijani Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Fatemeh Izadpanah Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Keywords: Metabolic syndrome, testosterone, aged

Abstract

Background and aims: Metabolic syndrome (MetS) is one of the critical health concerns. The relationship of low total testosterone and MetS was reported in some studies. However, the association independent of other related component is not fully known. This study performed to evaluate the prevalence rates of MetS among elderly men with and without hypogonadismin and the related association. Material and method: This cross - sectional study was conducted on all 800 male subjects aged 60 years and older. Anthropometric indices, blood pressure, serum total testosterone and serum lipid profile was determined. Iranian National Committee of Obesity criteria were used to define metabolic syndrome. Results: The mean total testosterone of MetS group was significantly lower than that of non-MetS. Total testosterone showed significant inverse associations with triglycerides and waist circumference. The crude odds ratio for Mets between the low and high total testosterone groups was 1.43 which remained statistically significant after adjustment, while total testosterone levels showed no significant association with MetS after adjusting with BMI. Conclusions: Testosterone is negatively and independently associated with MetS regarding age, smoking status and alcohol intake in Iranian men. Therefore, to MetS prevention the early diagnosis and treatment of hypogonadism should be considered