PREVALENCE OF HYPOGLYCEMIA, TREATMENT SATISFACTION, ADHERENCE AND THEIR ASSOCIATIONS WITH GLYCEMIC GOALS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH SULFONYLUREAS

FINDINGS FROM THE REAL-LIFE EFFECTIVENESS AND CARE PATTERNS OF DIABETES MANAGEMENT (RECAP-DM) IN ROMANIA

  • Simona Popoviciu University of Medicine and Pharmacy Oradea
  • Anca Alionescu Mersck Sharp & Dohme Romania SRL
  • Irma Sisic
Keywords: type 2 diabetes, sulfonylurea, hypoglycemia

Abstract

Background and aims: The aim of this study was to assess the prevalence and evaluate the impact on several treatment and quality of life parameters of hypoglycemia in type 2 diabetes mellitus patients treated with sulfonylureas (SU) in Romania. Secondary objective was to determine the proportion of patients attaining haemoglobin A1c (HbA1c) target of <7%. Material and method: This was a multi-center, observational study using retrospective clinical chart and laboratory parameters review, and a cross-sectional survey in Romania. The sample in this study consisted of 385 patients. Socio- demographic and clinical variables were compared between patients with inadequate and adequate control. Results: The mean age of all enrolled subjects was 65.37 (33-87) years. The average BMI was 30.44 kg/m2. Mean diabetes duration was 7.76 (6 months -32) years with the mean age of diabetes at diagnosis of 57.75 (31-85) years. HbA1c was recorded for 238 subjects with mean value of 7.12 (4.8-10.97) %. Conclusions: The prevalence of hypoglycaemia in SU treated patients was 42.2%. Highest prevalence was in the 50-60 age category, at 49.2% and lowest among the eldest subjects (>70 years), at 38.6%. Prevalence of patients at the goal of HbA1c<7% was 50.8 %. Patients with adequate glycaemic control had more acceptable BMI than those with inadequate glycaemic control. In patients not achieving a goal of HbA1c < 7%, higher level of plasma glucose and total cholesterol was determined compared to those with adequate glycaemic control. There were no significant differences in the HDL-C, triglycerides or albumin:creatinine ratios in patients with both adequate and inadequate glycaemic control.

Published
2019-04-09
How to Cite
Popoviciu, Simona, Anca Alionescu, and Irma Sisic. 2019. “PREVALENCE OF HYPOGLYCEMIA, TREATMENT SATISFACTION, ADHERENCE AND THEIR ASSOCIATIONS WITH GLYCEMIC GOALS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH SULFONYLUREAS”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26 (1), 55-64. http://www.rjdnmd.org/index.php/RJDNMD/article/view/599.
Section
Original Research Articles