OBSERVATIONAL CASE-CONTROL STUDY ON THE RISK FACTORS OF FETAL MACROSOMIA AND FETAL-MATERNAL ASSOCIATED PATHOLOGY

  • Delia Monica Glodean Doctoral School of Oradea
  • Diana Miclea
  • Gabriela Zaharie
  • Janina Mihaela Mihaila
  • Amorin Remus Popa
Keywords: macrosomia, large for gestational age, gestational diabetes

Abstract

Background and aims: The purpose of this study was to evaluate the frequency of demographic and clinical risk factors for fetal macrosomia, maternal pregestational, gestational and intra partum pathology associated with macrosomia, and to investigate the dynamic of these parameters in a decade. Material and method: We conducted two studies, a case-control study of 261 mothers who delivered macrosomic babies and 241 mothers who delivered normal weight babies in 2016, and then we compared the parameters obtained from the study group of 261women who delivered in 2016 macrosomic babies with those of a study group of 220 women who delivered macrosomic babies in 2006 at Gynecology I County Hospital of Cluj-Napoca. The data was stored and analyzed using Microsoft Excel. Results and conclusions: Overweight before pregnancy, the excessive weight gain during pregnancy, and the delivery of a macrosomic baby increase the risk to deliver in the future a macrosomic baby. Mothers who delivered macrosomic babies had a higher incidence of thyroid gland pathology (hypofunction) and gestational diabetes than those who delivered normal weight babies.

Overweight before pregnancy and the excessive weight gain during pregnancy are significant risk factors for fetal macrosomia. Gestational diabetes has a significant importance in the pathophysiology of fetal macrosomia, and gestational hypertension is a significant comorbidity. The delivery of a macrosomic baby increase the risk to deliver in the future a macrosomic baby. As birth injuries, the spontaneous delivery of a macrosomic baby increase the risk of maternal injuries at birth.

Published
2019-04-09
How to Cite
Glodean, Delia, Diana Miclea, Gabriela Zaharie, Janina Mihaila, and Amorin Popa. 2019. “OBSERVATIONAL CASE-CONTROL STUDY ON THE RISK FACTORS OF FETAL MACROSOMIA AND FETAL-MATERNAL ASSOCIATED PATHOLOGY”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26 (1), 11-19. http://www.rjdnmd.org/index.php/RJDNMD/article/view/546.
Section
Original Research Articles