OMEGA-3 POLYUNSATURATED FATTY ACIDS IMPROVED ARTERIAL STIFFNESS PARAMETERS IN TYPE 2 DIABETIC PATIENTS WITH CARDIAC AUTONOMIC NEUROPATHY
Background and Aims: Cardiovascular autonomic neuropathy (CAN) in type 2 diabetes mellitus (T2DM) is one of the independent risk factor for cardiovascular mortality. Material and Methods: 36 patients with T2DM and confirmed CAN were involved. The study was carried out on two separate arms: traditional hypoglycemic therapy (n = 15, control) and long-chain w-3 polyunsaturated fatty acids (w-3 PUFAs, n = 21). The duration of the study was three month. Results: In subjects with T2DM and СAN treatment with w-3 PUFAs resulted in a significant decrease of aorta augmentation index (AIxao), pulse wave velocity (PWV) during the active period of the day and decrease of AIxao, brachial augmentation index and PWV during the passive period of the day compared with the control group. Therefore, the administration of omega-3 PUFAs to patients with T2DM for three months promotes to improvement of arterial stiffness parameters. Conclusions: In patients with T2DM and СAN treatment with w-3 PUFAs improved arterial stiffness parameters. The efficacy of w-3 PUFAs is not associated with improved glycaemic control, but is rather the result of a direct effect of the pharmacological agent on the investigated indexes.