SUBCLINICAL DIASTOLIC DYSFUNCTION AND ITS CORRELATION WITH LABORATORY PARAMETERS IN TYPE 2 DIABETES MELLITUS IN INDIA: A CASE CONTROL STUDY

Subclinical diastolic dysfunction in Diabetes Mellitus

Abstract

Background: This study was conducted to determine left ventricular dysfunction in diabetics and to find correlation with glycemic control and biochemical parameters compared to non-diabetic population. Methods: Thirty type 2 diabetics and thirty non diabetic controls were recruited. Age, sex, body mass index of the controls were matched. Results: Mean duration of diabetes mellitus in study population was 10.97± 4.01years. Among study population whole study population including cases and controls had ejection fraction >55%. Among cases 53.3% were having mean E/A ratio <1 and 46.67% were had mean E/A ratio >1.In controls all of them having mean E/A ratio above 1. This difference of mean E/A ratio among cases and controls statistically significant (p<0.0001). Among diabetic cases 9.09%  cases with HbA1C range 6-7%, 33.33% of cases with HbA1C range 7.1-8%, 100% of cases with HbA1C range >8.1% were showing diastolic dysfunction which is statistically significant (p<0.0001). LDL was having weak negative correlation with E/A ratio (correlation coefficient(cc) = -0.38) while Fasting blood sugar(coefficient  -0.53) and HbA1C(coefficient -0.66) was having moderate negative correlation. All these correlations were statistically significant. Conclusion: Subclinical diastolic dysfunction is prevalent among diabetic population . Diastolic dysfunction in diabetics showed positive correlation with FBS, HbA1C and LDL.