HYPERGLYCEMIA DURING ACUTE MYOCARDIAL INFARCTION IN DIABETIC AND NONDIABETIC PATIENTS

Radu Lichiardopol; N. Niculescu; Anca Totora; Cornelia Pencea; Sorin Ioacara; I. Tomescu; Mircea Cinteza

Radu Lichiardopol
N. Niculescu
Anca Totora
Cornelia Pencea
Sorin Ioacara
I. Tomescu
Mircea Cinteza

Keywords: adiponectin, leptin, resistin, CRP, TNF α, insulin resistance, MetSyn, obesity

Abstract

Adipokines and cytokines have modified values in the metabolic syndrome (MetSyn), without knowing if they are the cause or the effect of insulin resistance. Multiple studies evaluating adipokines and cytokines in endocrinopathies associating MetSyn presented controversial results.
The aim of this study was to evaluate adiponectin, leptin, resistin, CRP and TNFα in obese subjects with different endocrine diseases that associate also insulin resistance.
Subjects and methods: This study enrolled 59 subjects (male and female), that were clinically evaluated. Blood samples were taken in fasting conditions in order to determine the biochemical profile, adipokine and cytokine levels; insulin resistance was appreciated using HOMA index. The MetSyn was diagnosed according to DIF criteria of definition.
Results were statistically analyzed using SPSS program, version 15.
Results: Subjects were divided into 2 groups-37 subjects with MetSyn (the study group), and 22 subjects- control group (age matching controls).
Compared mean values from both groups, revealed statistically significant differences for both groups regarding BMI (p=0.05), waist circumference (p=0.009), triglycerides (p<0.001), HDL-cholesterol (p<0.001), diastolic blood pressure (p=0.012), leptin (p=0.005), insulin (p=0.049), glycaemia (p=0.013), HOMA (p=0.033) and TNF α (p=0.026).
Adiponectin values were low, leptin levels were high and resistin concentration was normal in both groups, without any differences regarding the associated endocrine disease. Although adiponectin levels were lower and CRP higher in the MetSyn group, these results did not reach a statistical significance.
Conclusions: Obese subjects with different endocrine diseases that associate MetSyn have low levels of adiponectin, high leptin, CRP and TNF α values and normal resistin concentrations without being influenced by the associated endocrinopathy.