HIGH PREVALENCE OF METABOLIC DISORDERS IN PSORIASIS PATIENTS

Abstract

Recent studies have shown that psoriasis is a systemic disorder associated with an increased prevalence of metabolic anomalies. This study compares the prevalence of obesity and metabolic disorders in psoriasis patients and the general population. 302 patients and 621 controls were included in a retrospective case control study. We compared the proportion of obesity, diabetes, and dyslipidemia between case and control groups. Psoriasis patients had higher odds of diabetes (OR 1.97; 95% CI, 1.36-2.86), dyslipidemia (OR 1.76; 95% CI, 1.31-2.37), and obesity (OR 2.84; 95% CI 1.87-4.31) compared with controls. The risk of dyslipidemia and obesity correlated with disease severity. The long term management of psoriasis patients should address not only the cutaneous and joint manifestations, but also the prevention and correction of eventual associated metabolic disorders.