THE RELATIONSHIP BETWEEN sE-Selectin CONCENTRATIONS, MICROALBUMINURIA AND INSULIN-SENSITIVITY IN TYPE 2 DIABETES PATIENTS

Abstract

The aim of the study was to examine the effects of poor metabolic control on vascular endothelium, expressed by increased soluble E-selectin concentration, microalbuminuria and their relationship with insulin sensitivity in type 2 diabetes. We studied 42 patients with type 2 diabetes and 36 subjects without diabetes. The patients with type 2 diabetes were divided in two study subgroup: group A (HbA1c<8%) and group B (HbA1c≥ 8%). Patients with type 2 diabetes had both significantly high levels of sE-selectin and AER compared with control subjects (p<0.001). A poor metabolic control, expressed by a difference in HbA1c of 1.4% (mean value) between group A and group B, resulted in a significant increase of sE-selectin (p<0.001), suggesting endothelial damage. In patients with type 2 diabetes, poor metabolic control influences sE-selectin and microalbuminuria. We found a positive correlation between these two markers of endothelial dysfunction.