Is HS-CRP useful in identifying a subset of normal-weight women with higher cardiovascular risk?

  • Vahideh Aghamohammadi Department of Nutrition, Khalkhal University of Medical Sciences, Khalkahl, Iran
  • Meysam Alipour Department of Nutrition, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
  • Damoon Ashtary-Larky Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Hadi Bazyar Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  • Neda Haghighat Laparoscopy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Khadijeh Nasiri Department of Nutrition, Khalkhal University of Medical Sciences, Khalkahl, Iran
  • Amir Abbasnezhad Department of Nutrition, Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Keywords: cardiovascular disease, C-Reactive Protein, obesity

Abstract

Due to the paucity of information on high-sensitivity C-Reactive Protein (hs-CRP) identifying an at-risk group of non-obese individuals with a higher risk of subclinical atherosclerosis, we decided to evaluate hs-CRP identifying cardiovascular risks on inflammatory obesity phenotypes. We studied 154 women aged 20–35 years. Inflammatory status was defined as a serum hs-CRP level ≥2 mg/L. Individuals were grouped according to inflammatory obesity phenotypes: 1) IHNW: inflammatory healthy normal weight, 2) IUNW: inflammatory unhealthy normal weight, 3) IHO: inflammatory healthy obese, 4) IUO: inflammatory unhealthy obese. Body composition was significantly better in the IHO group compared to the IUO group(P<0.001), except for lean body mass in the left and right leg. After adjustment for covariates, the IHNW and IUNW had significant differences in hs-CRP, FBS and lipid profile(P<0.05). The IUO phenotype individuals had significantly more Cho/HDL, LDL/HDL and Atherogenic Index of Plasma(P<0.05). Moreover, the HOMA-s percentage was significantly higher in the IHO group compared to the IUO group. In conclusion, hsCRP ≥2 mg/L is useful in identifying a subset of obese and non-obese women with higher CVD risk. High hs-CRP, in the absence of obesity, could distinguish non-obese subset subjects with cardiovascular risk.

Published
2024-03-31
How to Cite
Aghamohammadi, Vahideh, Meysam Alipour, Damoon Ashtary-Larky, Hadi Bazyar, Neda Haghighat, Khadijeh Nasiri, and Amir Abbasnezhad. 2024. “Is HS-CRP Useful in Identifying a Subset of Normal-Weight Women With Higher Cardiovascular Risk?”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 31 (1), 57-64. http://www.rjdnmd.org/index.php/RJDNMD/article/view/1006.