Association of FTO gene (rs9939609) with obesity and type-2 diabetes mellitus: Review from current studies

Abstract

Obesity and type-2 diabetes mellitus (T2DM) has become a common and increasingly growing chronic non-communicable disease worldwide with potentially devastating complications and FTO gene (rs9939609) are found to be associated with obesity                                                                                                                                                                                                                            and type-2 diabetes mellitus (T2DM) in several studies. So, the present review is aimed to investigate the current understanding of the effect of FTO gene (rs9939609) with the obesity and type-2 diabetes mellitus (T2DM). PubMed, Medline, Google scholar, Cochrane library and several other databases were searched up from 2000 to 2019 to identify and select relevant studies. Research conducted using human are only considered for eligible. Among the seventeen prospective cohort studies, two have found no significant association between FTO gene and type-2 diabetes, four studies revealed an association of FTO gene with obesity and type-2 diabetes and eleven studies identified positive association of FTO gene with obesity. The current study confirmed the significant association of FTO gene with risk of obesity and type-2 diabetes mellitus. Further studies should be conducted to identify the causal variant and the underlying mechanisms of the identified association.