Romanian Journal of Diabetes Nutrition and Metabolic Diseases
https://www.rjdnmd.org/index.php/RJDNMD
<p>The <strong>Romanian Journal of Diabetes Nutrition and Metabolic Diseases</strong> is the journal of the <strong>Romanian Society of Diabetes Nutrition and Metabolic Diseases</strong>.</p> <p>It appeared for the first time in 1992, in Romanian language and beginning with 2006 it was published entirely in English. It is a peer reviewed journal, therefore the accepted articles were peer-reviewed by <strong>at least two scientific experts</strong> in the field.</p> <p>It contains <strong>original papers</strong>, including fundamental and clinical research, <strong>literature reviews</strong>, <strong>clinical reports</strong>, <strong>editorials</strong>, articles that contain the <strong>results of the most important clinical studies</strong>, reports from the important congresses and <strong>book reviews</strong>. </p> <p>In Romanian Journal of Diabetes Nutrition and Metabolic Diseases there may be published only papers exclusively sent to this journal, not published previously. The authors should include possible conflicts of interest and financing sources. The laws of copyright and international rules of scientific research are respected.</p> <p>The Romanian Journal of Diabetes Nutrition and Metabolic Diseases <strong>strictly requires</strong> for all the scientific work published <strong>to be 100% compliant</strong> with the <a title="ICMJE.ORG" href="http://www.icmje.org/icmje-recommendations.pdf" target="_blank" rel="noopener">Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals</a> and with the <a title="Best Practices" href="http://doaj.org/bestpractice" target="_blank" rel="noopener">Principles of Transparency and Best Practice in Scholarly Publishing</a> (joint statement by COPE, DOAJ, WAME, and OASPA).</p> <p>This journal appears trimestrially (four numbers/year). 650-800 copies are printed on each number.</p> <p>ILEX Printing House, Bucharest, has the exclusivity for the typesetting, printing and distribution of the Romanian Journal of Diabetes, Nutrition and Metabolic Diseases.</p> <p>Our journal is recognized by the Romanian National University Research Council (CNCSIS - 2009) to be part in the B+ category, Code 322.</p> <p>The Romanian Journal of Diabetes Nutrition and Metabolic Diseases is currently indexed in:</p> <p>- Index Copernicus<br>- Get Cited<br>- SCOPUS<br>- Scirus<br>- Celdes<br>- CNKI Scholar (China National Knowledge Infrastucture)<br>- CNPIEC<br>- EBSCO - TOC Premier<br>- EBSCO Discovery Service<br>- Google Scholar<br>- J-Gate<br>- Naviga (Softweco)<br>- Primo Central (ExLibris)<br>- SCImago (SJR)<br>- Summon (Serials Solutions/ProQuest)<br>- TDOne (TDNet)<br>- Ulrich's Periodicals Directory/ulrichsweb<br>- WorldCat (OCLC)</p>Romanian Society of Diabetes Nutrition and Metabolic Diseasesen-USRomanian Journal of Diabetes Nutrition and Metabolic Diseases2068-8245Study of level of netrin-1 in serum of patients with type 2 diabetic nephropathy
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1768
<p>Diabetic nephropathy is among the devastating outcomes of diabetes. An essential part of slowing its development is early detection. The goal was to determine the impact of netrin-1 on microalbuminuria and early detection of nephropathy type 2 DM. This trial was conducted on 120 patients divided equally into four groups: group (1) Healthy normal persons; group (2) patients with type 2 DM without albuminuria (albumin/creatinine ratio <30 mg/gm), group (3) patients with type 2 DM with microalbuminuria (albumin creatinine ratio 30–299 mg/gm), and group (4) patients with type 2 DM with overt proteinuria (albumin creatinine ratio ≥300 mg/gm). All participants were subjected to complete history taking, full clinical examination, routine labs, and Netrin-1 level. The highest level of Netrin-1 was found in group 4 (56.2±20.5), followed by group 3 (43.2±22.4), group 2 (36±13.4), and group 1 (33.2±10.8) (P-value <0.001). In addition, there was a significantly higher Netrin-1 level in diabetic nephropathy patients (49.7±22.3) than in patients without nephropathy (34.6±12.1) (P-value <0.001). Plasma netrin-1 level is significantly elevated in patients with diabetic nephropathy, whether micro or macro proteinuria, and there is a future hope for the possibility of using netrin 1 as an early predictor for the diagnosis of diabetic nephropathy.</p>Mahmoud Mohamed NaiemKhaled Elsayed ElhadidyHanan Hosni MoawadAhmed Moheyeldien HamedMohamed Ragab Ahmed
##submission.copyrightStatement##
2024-12-162024-12-16314363370Antidiabetic effect of a GABA-supporting mixture in a streptozotocin-induced diabetes model in rats
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1776
<p>Gamma-aminobutyric acid, GABA, can stimulate the growth and viability of pancreatic β-cells, normalizing blood glucose levels. Our study aimed to investigate the antidiabetic effects of a GABA-supporting mixture (GSM) containing asparagine, glutamine, β-alanine, and ethanolamine-O-sulfate in a streptozotocin-induced diabetes model in rats. The animals with diabetes were injected with GSM daily for 5 days, followed by controlling glycemic status and measuring the activity of enzymes involved in the synthesis of GABA, glutaminase (GLS), and glutamate decarboxylase (GAD). Glucose levels in healthy (Control), diabetes (STZ), and GSM treated (STZ-GSM) animals were 4.48±0.3, 23.09±2.3, and 12.94±2.03 mM/L, respectively. The GAD activity in the same three groups was in homogenates of: brain 783±23, 1022±34, 829±33 IU/mg; pancreas 793±34, 1079±55, 857±58 IU/mg; liver 643±33, 804±15, 690±35 IU/mg, respectively. The GLS activity in these groups was: in the blood plasma 26±3, 78±6, 46±5 IU/mg; in homogenates: brain 83±2, 71±3, 86±3 IU/mg; pancreas 150±20, 220±25, 170±22 IU/mg; liver 59±5, 52±6, 81±7 IU/mg, respectively. Increased liver GLS in the STZ-GSM group indicated GABA support by GSM through an increase in GABA precursor glutamine. Conclusion: GSM improves glycemic status, GLS, and GAD activity in STZ-diabetic animals, confirming its applicability in the treatment of diabetes.</p>Narine KhachatryanRima BalagyozyanValentina BalagyozyanGayane HekimyanGohar GrigoryanSona MardanyanAlvard Antonyan
##submission.copyrightStatement##
2024-12-162024-12-16314371378Importance of metabolic factors in determining cardiovascular risk in romanian patients with type 1 diabetes: A pilot study
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1830
<p>A major cause of morbidity and mortality in patients with type 1 diabetes is cardiovascular disease. Cardiovascular risk in these patients should be periodically evaluated, and the Steno T1 Risk Engine can be a useful tool in determining five- and ten-year cardiovascular risk in patients with type 1 diabetes. The current aim of this study was to evaluate the link between cardiovascular risk in a population of Romanian patients with type 1 diabetes and metabolic control. The current study is a non-interventional, population-based, retrospective, single-center study in which 38 patients were enrolled on a consecutive case basis from the Diabetes Clinic of the Pius Brinzeu Emergency County Hospital Timisoara. Anthropological and laboratory tests were collected in order to cluster patients into three cardiovascular risk categories. Statistical analysis was performed using GraphPad Prism Software version 10.4.0. The threshold for statistical significance in this study was a p-value under 0.05. In most cases, patients were at a medium five-year cardiovascular risk (47.37%), while in the case of ten-year cardiovascular risk, most patients were in the high category (78.38%). No difference was found in cardiovascular risk levels between male and female patients, and achieving glucose control was shown to improve cardiovascular risk significantly more than achieving lipid control. Improving glucose and lipid control by achieving and maintaining the target for HbA1c and LDLc, respectively, reduces cardiovascular risk, with the former having a greater magnitude to the impact.</p>Andreea HerascuVlad AvramLaura GaitaAdina BrahaAlexandra SimaBogdan Timar
##submission.copyrightStatement##
2024-12-162024-12-16314379385The effect of a plant-based diet in post-surgical bariatric surgery patients in a reference obesity unit in Mexico
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1761
<p>Post-bariatric surgery patients need nutritional treatment after surgery, focusing on preventing patients from developing dietary deficiencies. This study analyzed the effect of a plant-based diet in post-bariatric surgery patients. A cohort study compared the anthropometric and biochemical parameters from two groups of adult patients. One group followed a conventional diet (n=30), and the other followed a plant-based diet (ovolactovegetarian) (n=20). Two measurements were performed, the first at the beginning of treatment and the second six months later. After six months of dietary follow-up assisted by a nutrition professional, both groups had similar weight loss percentages, BMI, waist circumference, and visceral fat score. Related to anthropometric indicators, only fat mass loss percentage had significant differences, which was higher in the conventional diet group. In regard to biochemical values, similar albumin, glucose, and iron-blood values were found in both groups after six months of treatment. The group of patients who performed a plant-based diet reached similar biochemical and anthropometric values as those found in the conventional diet group after a six-month period.</p>Estefanía Gasca SuárezClaudia Lizett GarcíaNancy Rosas CortezMartha Patricia Sánchez-MuñozFrida Jocelyn Cuellar VacaYajaira Lizeth Parga Gallegos
##submission.copyrightStatement##
2024-12-162024-12-16314386392The state of the immune system in patients with cardio rheumatic diseases and concomitant metabolic-associated liver steatosis
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1705
<p>Liver steatosis, the earliest stage of metabolic-associated non-alcoholic fatty liver disease (MAFLD), is the most common form of liver damage. However, the specific immune response linked to this condition remains poorly understood. This study aimed to assess immune system parameters and their relationships in patients with cardiorheumatic diseases who also have metabolic-associated liver steatosis (MALS). A total of 53 patients were included in the study: 32.07% had ischemic heart disease, 39.62% had haemorrhagic vasculitis, and 28.31% had rheumatic fever. Various immune parameters were measured, including different lymphocyte subtypes, immunoglobulin levels, immune complexes, complement components, and phagocyte activity. In patients with MALS, immune disturbances were characterized by significant shifts in B-cell activity, elevated immune-effector indices, increased small immune complexes, and complement component levels. Low-affinity B-cells emerged as central in immune system interactions, showing significant correlations with various immune cells, such as T-cells, T-suppressors, NK cells, and IL-2 receptor-bearing T-cells, as well as with the immunoeffector index. Key immune mechanisms associated with MALS included activation of the humoral immune response, the complement system, immune complex formation, and enhanced antibacterial activity in phagocytes.</p>Orest KomarytsiaOlena RadchenkoOlga KoroliukSerhii StadnikNataliya Bek
##submission.copyrightStatement##
2024-12-162024-12-16314393398The effectiveness of an integrated program in controlling sexual dysfunction in patients with diabetes aged 45–50 years
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1728
<p>Diabetes mellitus is a serious health condition that, if poorly managed, can lead to various complications, including sexual dysfunction, particularly in men. This study examined the effects of a comprehensive intervention program on 10 men aged 45–50 with type II diabetes over three years. Monthly follow-ups assessed changes in sexual activity frequency, body weight, and HbA1c levels. Results showed a consistent frequency of sexual activity and improvements in body weight and HbA1c across all participants, suggesting that the program supported better diabetes management and reduced the risk of sexual dysfunction. Based on these promising results, we recommend implementing this intervention with a larger group to further evaluate its effectiveness and potential benefits for diabetes management and related complications.</p>Ata Emad Ata AliNader Ahmad Jaradat
##submission.copyrightStatement##
2024-12-162024-12-16314399403The predictive utility of one-hour plasma glucose in oral glucose tolerance test: A study of 231 nondiabetic patients
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1787
<p>This study aims to assess the predictive value of one-hour plasma glucose levels (1h-PG) in identifying high-risk individuals for type 2 diabetes mellitus (T2DM) among nondiabetic patients. A prospective analysis was conducted on 231 patients at Constanța Emergency Hospital, using Oral Glucose Tolerance Tests (OGTT) with measurements at 0, 30, 60, and 120 minutes. The 1h-PG was compared with fasting plasma glucose (FPG) and 2-hour plasma glucose (2h-PG) to determine its diagnostic sensitivity and utility in screening for prediabetes and diabetes. Our findings, supported by recent studies, indicate that 1h-PG offers greater sensitivity in detecting early dysglycemia compared to traditional measures. Targeted early screening can reduce the incidence of diabetes-related complications.</p>Florin Gabriel PanculescuDoina CatrinoiuCristina Maria MihaiTatiana Chisnoiu
##submission.copyrightStatement##
2024-12-162024-12-16314404410Peculiarities of transtubular transport of calcium and phosphates in the dynamics of the development of alloxan-induced experimental Diabetes Mellitus
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1736
<p>The objectives of the research were to study the peculiarities of the intrarenal mechanisms of calcium and phosphates homeostasis regulation under the condition of experimental diabetes. The experiments were carried out on 54 white non-linear mature male rats – 24 animals with 11-, 26- and 46-day long alloxan-induced experimental diabetes mellitus and 30 intact animals of the control. Creatinine, sodium, calcium and phosphates in the urine were determined. Electrolytes excretion, calcium-phosphorus, calcium- and phosphorus-creatinine, sodium-calcium and sodium-phosphorus ratios in urine were calculated. The study’s results demonstrated the increase of sodium-dependent excretion of calcium and phosphates, mainly hyperfusional in nature, on the 11th day of the experiment provided by the distal tubules with underlying functional overstrain of the tubulo-tubular feedback. The predominance of sodium-dependent distal counter-transport of calcium was preserved on the 26th day of the experiment, while phosphate reabsorption was related mainly to the proximal tubules. Reabsorptive defect of phosphates in the proximal and distal tubules was a probable reason for the increase of their urine content and maximal strain of phosphate homeostasis mechanisms on the 46th day of the experiment, preserved concerning calcium. These results evidence the preserved compensatory and functional autoregulatory renal mechanisms for calcium and phosphate exchange.</p>Olha OlenovychAnatoliy GozhenkoYelyzaveta Tkach
##submission.copyrightStatement##
2024-12-162024-12-16314411419Prediabetes, undiagnosed diabetes, and associated factors in North Sumatra, Indonesia: A community-based study
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1745
<p>Diabetes causes disability, morbidity, and cost burden. It develops faster in individuals with prediabetes. Approximately 50% of patients with diabetes remain undiagnosed until physical complications appear. This study aimed to determine the prevalence of prediabetes and undiagnosed diabetes based on fasting blood glucose levels and associated factors in a community in Indonesia. This community-based cross-sectional study applied the convenience sampling technique. Participants included 412 adults without a history of type 2 diabetes. The fasting blood sugar levels of the respondents were measured after fasting for at least eight hours. The American Diabetes Association guidelines were followed to identify individuals with prediabetes and undiagnosed diabetes. The study results revealed a 27% prevalence of prediabetes and a 20% prevalence of undiagnosed diabetes in the respondents. The bivariate analysis did not show any significant difference between the risks of normoglycemia and prediabetes. However, three significantly different diabetes risk variables were identified between normoglycemia and undiagnosed diabetes: age, having experienced elevated blood glucose levels during a health check-up, and having a family member who has diabetes (p<0.05). The incidences of prediabetes and undiagnosed diabetes were high among the study population. Therefore, efforts should be made to prevent the development of prediabetes into diabetes and to manage individuals with undiagnosed diabetes to reduce its prevalence and complications in the future.</p>Mula TariganSetiawan SetiawanEka Roina Megawati
##submission.copyrightStatement##
2024-12-162024-12-16314420427Study of the vacuum therapy influence on the wound process in patients with diabetic foot syndrome
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1741
<p>An open, observational, multicenter, retrospective, randomized, controlled, comparative study of patients in the main and control groups of patients was carried out. Patients were assigned using a table of random numbers. The mixed form of the lesion was not isolated separately, and the patients of this group were divided between neuropathic (NF) and ischemic (IF) forms, respectively, with the peripheral hemodynamics rate. The participants were also divided into patients with acute and chronic wounds. In patients with NF SDS, the formation of healthy granulation tissue began at (4.61±0.96) days, and before (6.43±0.48), the wound surfaces were ready for plastic closure by one of the methods of plastic surgery (imposition of secondary sutures, autodermoplasty). In the control group, plastic wound closure was possible only from (9.42±1.46) days (p<0.05).In patients with IF SDS, the formation of granulation tissue began on (6.53±1.14) days (p<0.02), and the wounds were ready for plastic closure on (8.76±1.25) days (control group – 12.48±1.94 days) (p<0.05). This, in turn, allows to be prepared in a shorter time the wound for closure using one of the methods of plastic surgery or to create favorable conditions for its independent epithelialization. Vacuum therapy can be used in the local treatment of acute and chronic wounds in patients with different pathogenetic forms of DFS and a positive effect is highly expected. It allows the stabilization of the course of the wound process, improves local microcirculation, and stimulates regenerative processes in the tissue.</p>Petro Oleksandrovych GerasymchukAndrii Volodymyrovych PavlyshynDmytro Bohdanovych FiraNataliia Volodymyrivna Volotovska
##submission.copyrightStatement##
2024-12-162024-12-16314428432Unveiling the hidden culprits: exploring fungal infections and risk factors in chronic suppurative inflammation of the middle ear
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1702
<p>This study investigated the prevalence, distribution of fungal species, antifungal susceptibility, and risk factors associated with fungal infections in chronic suppurative inflammation of the middle ear across different age groups. A total of 150 cases were included in the study, comprising pediatric, adult, and elderly populations. The prevalence of fungal infections varied among the age groups, with the highest prevalence observed in the elderly population (48.0%), followed by pediatric patients (33.3%) and adult patients (26.7%). Aspergillus and Candida were the most prevalent fungal species across all age groups, while other species, such as Cryptococcus, Fusarium, and Rhizopus, showed varying prevalence levels. Antifungal susceptibility testing revealed that Amphotericin B exhibited the highest efficacy (80%), followed by Voriconazole (70%) and Fluconazole (60%). However, a certain percentage of isolates showed intermediate susceptibility or resistance to these agents. An analysis of risk factors indicated that diabetes and previous antibiotic usage were significantly associated with fungal infections, while HIV infection and occupational factors did not show significant associations. These findings provide valuable insights into the prevalence, distribution, antifungal susceptibility, and risk factors of fungal infections in chronic suppurative inflammation of the middle ear, guiding clinicians in understanding the susceptibility of different age groups and facilitating the development of targeted diagnostic and therapeutic strategies.</p>Haifa Munif AlnahdiYasser Hussein Issa Mohammed
##submission.copyrightStatement##
2024-12-162024-12-16314433440The impact of glycemic control on heart rate variability in patients with type 2 Diabetes Mellitus and the potential for prediction
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1797
<p>The objective was to ascertain whether glycemic control impacts heart rate variability in patients with type 2 diabetes and determine whether alterations in heart rate variability can be anticipated through continuous glucose monitoring data analysis. A total of 53 adult patients with type 2 diabetes (T2DM) and a glycosylated level (HbA1c) of ≤10% were examined. The study was based on the synchronous recording of heart rate variability and continuous glucose monitoring (CGM) before and six months after the modification of glucose-lowering therapy. Correlation, logistic regression, and receiver operating characteristic (ROC) analyses were employed. Following a six-month period, patients exhibited a notable reduction in HbA1c, time above range, time below range, glycemic variability, and a decline in the frequency of hypoglycemic episodes. The presence of hypoglycemia before the modification of glucose-lowering therapy was identified as a prognostic factor for predicting HRV improvement. The study’s findings suggest enhanced glycemic control is associated with increased absolute all-time and frequency domain characteristics of HRV. A mathematical model for HRV prediction based on CGM parameters for T2DM was developed, exhibiting a sensitivity of 60.0% and a specificity of 83.33%.</p>Kateryna MoshenetsNataliia Pertseva
##submission.copyrightStatement##
2024-12-162024-12-16314441447Analysis of the nutritional content and acceptability of instant tiwul as a substitute for mocaf flour, green bean flour and jali flour as a high-fiber snack for type 2 diabetes mellitus
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1746
<p>Instant tiwul is a traditional staple food consumed by Javanese people, especially in rural areas and remote mountains. The fiber content in mocaf (cassava) flour is 1.36 g/100g. Green beans have a fiber content of 11.2%. The drying process can extend the shelf life of instant tiwul products. The aim of this research was to determine the effect of the proportion of mocaf flour and green bean flour as well as the effect on sensory characteristic values and nutritional value. Determining the best formulation of instant tiwul products according to consumer assessment. This research used a Completely Randomized Design (CRD) method with 3 treatments. The highest fiber content test results and the best formulation were obtained in instant tiwul from the comparison treatment of 85% mocaf flour and 15% green bean flour. Instant tiwul, made from mocaf flour and green bean flour, has the potential to be a nutritious food that is high in fiber for people with type 2 diabetes mellitus.</p>Zuhria IsmawantiSetyo PrihatinArvina Dian Wahyu PermatasariTiara FirnandaUlin Nafi'ahZahwa Mahda ZhurifaArwin MuhlishohOktavina PermatasariAryanti Setyaningsih
##submission.copyrightStatement##
2024-12-162024-12-16314448453The influence of Atherophyton on the development of low-grade inflammation in experimental metabolic syndrome in Syrian golden hamsters
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1663
<p>The study aimed to investigate the effect of the dietary supplement (DS) Atherophyton on the development of low-grade inflammation by assessing the effect of such cytokines against the background of experimental metabolic syndrome in Syrian golden hamsters. The experimental metabolic syndrome (EMS) in Syrian golden hamsters was induced by keeping the animals for 24 days on a diet enriched with fructose (60% of the total daily diet with complete replacement of drinking with a 10% fructose solution). According to our experimental study, in the conditions of EMS, the leading role in the pathogenesis of which is associated with the development of oxidative stress and subsequent activation of chronic subcellular inflammation, the use of Atherophyton contributed to the suppression of low-grade inflammation, as indicated by a decrease in cytokine levels: IL-1β, IL-6, TNF-α by 1.5 (p<0.05), 1.8 (p<0.05) and 1.7 (p<0.05) times, respectively, which in turn is due to the ability of biologically active substances of medicinal plant materials included in Atherophyton to affect the etiopathogenetic component EMS development and, accordingly, the chronic sub-inflammatory process. DS Atherophyton suppresses the development of low-grade inflammation against the background of EMS in Syrian golden hamsters.</p>Kateryna KalkoMaksym MirzebasovSerhii SmirnovIryna BorisyukDmytro SemenivYuliana BukataruOlga Sadovnyk
##submission.copyrightStatement##
2024-12-162024-12-16314454458Optimizing glycaemic control in a complex T2DM patient using basal-bolus insulin and continuous glucose monitoring
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1796
<p>This case study presents the management of a 65-year-old female with Type 2 Diabetes Mellitus (T2DM), renal impairment and hypertension who experienced significant glycaemic variability and recurrent hypoglycaemic events. Due to poor control of a premixed insulin regimen, a shift to basal-bolus insulin therapy combined with intermittent continuous glucose monitoring (CGM) was implemented. This approach improved glycaemic control, increased percentage time in target range (TIR), and reduced hypoglycemia, highlighting the effectiveness of personalized insulin management and patient engagement in glycaemic monitoring.</p>Suhas Gopal ErandeAbhijit Anil TrailokyaAvinash Wamanrao Talware
##submission.copyrightStatement##
2024-12-162024-12-16314459465Glucagon-like peptide-1 receptor agonist (GLP-1-RAS) treatment in patients with cirrhosis: A scoping review
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1553
<p>Cirrhosis is a chronic disease characterized by diffuse fibrosis and morphological changes in the hepatic parenchyma. It is estimated that one-third of patients with cirrhosis also have diabetes. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown significant benefits in managing liver diseases, such as nonalcoholic fatty liver disease. However, little is known about its utility in patients with cirrhosis. This study aimed to explore the existing literature on the use of GLP-1 analogs in patients with hepatic cirrhosis, examining their potential advantages and disadvantages and possible indications for their use. Scoping reviews that included PubMed, Scopus, the International Clinical Trials Registry Platform search portal and ClinicalTrials were used. Six publications were included: prospective cohort (n=1), retrospective cohort (n=3), and clinical trial (n=2). The use of GLP-1 RAs proved beneficial in cirrhosis, demonstrating a decrease in mortality and complications and a reduction in weight. Using them over other available antidiabetic agents in this patient population is preferable. However, GLP-1 analogs in advanced fibrosis stages do not appear to be effective in reversing this condition.</p>Juan Sebastián Hernández PuentesCarlos Andrés Granados BurgosNatalia Sofia Jiménez NovoaAthala Inés Larrarte GonzálezMaría Fernanda Velasco BecerraLaura Daniela Bilbao RubianoValentina Puentes Caycedo
##submission.copyrightStatement##
2024-12-162024-12-16314466473Analgesic effect of non-invasive neuromodulation approaches among patients with diabetic peripheral neuropathy: A systematic review
https://www.rjdnmd.org/index.php/RJDNMD/article/view/1559
<p>Diabetic peripheral neuropathy (DPN), a complication of Diabetes Mellitus, is increasingly contributing to global morbidity and mortality. Non-invasive neuromodulation (NINM) approaches have become popular as safe, effective, and non-intrusive methods for managing persistent neuropathic pain. A key strategy for addressing DPN symptoms, neuromodulation modifies nerve function and encourages plastic changes in the central nervous system, aiding pain relief. This review aims to systematically assess scientific literature on the safety and effectiveness of NINM in reducing pain and improving physical function in DPN patients. Using PRISMA guidelines, searches were conducted across electronic databases such as MEDLINE (via PubMed), Web of Science, ScienceDirect, Cochrane, and PEDro, with study quality assessed using the PEDro scale. Fourteen studies with 436 participants were analyzed, revealing that NINM approaches can access deeper cortical regions without invasion, causing beneficial changes in the primary motor cortex (M1) that promote adaptive responses and activate pain control mechanisms without significant side effects. NINM shows promise in reducing neuropathic pain, evidenced by improved pain scores and physical function, leading to enhanced quality of life for patients suffering from chronic DPN-related pain.</p>Khushboo KumariNidhi SharmaAbhishek SharmaAksh ChahalSidharth Bansal
##submission.copyrightStatement##
2024-12-162024-12-16314474488