Morphological assessment of structural reorganization of the testicular hemomicrocirculatory bed under conditions of diabetes mellitus and burn trauma

Serhiy Konovalenko; Myroslav Kritsak; Irina Dzevulska; Ruzhena Matkivska; Rostyslav Kaminsky; Valentyn Tytarenko; Iryna Ibrahimova

Serhiy Konovalenko Department of Descriptive and Clinical Anatomy, Bogomolets National Medical University Kyiv, Kyiv, Ukraine
Myroslav Kritsak Department of Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Irina Dzevulska Department of Descriptive and Clinical Anatomy, Bogomolets National Medical University Kyiv, Kyiv, Ukraine
Ruzhena Matkivska Department of Descriptive and Clinical Anatomy, Bogomolets National Medical University Kyiv, Kyiv, Ukraine
Rostyslav Kaminsky Department of Descriptive and Clinical Anatomy, Bogomolets National Medical University Kyiv, Kyiv, Ukraine
Valentyn Tytarenko Department of Descriptive and Clinical Anatomy, Bogomolets National Medical University Kyiv, Kyiv, Ukraine
Iryna Ibrahimova Department of Descriptive and Clinical Anatomy, Bogomolets National Medical University Kyiv, Kyiv, Ukraine

Keywords: testis, microcirculation, morphometry, diabetes mellitus, burns, reproductive health

Abstract

The study of structural changes in the testes under conditions of common pathologies, such as diabetes mellitus and burn disease, is extremely important due to their systemic impact on the vascular system and the high risk of developing multiple organ failure. The aim of this work was to conduct a morphometric assessment of the structural reorganization of the testicular hemomicrocirculatory bed in experimental diabetes mellitus, burn injury, and their combination. The study was conducted on 43 white male rats. The diameters of arterioles, capillaries, and venules, as well as the density of microvessels, were determined morphometrically. It was established that in all pathological conditions, there is a narrowing of the arterial link and an expansion of the venous link. The degree of pathological reorganization was more prominent in the left testis. The most pronounced changes were recorded in the combination of diabetes and burn: the diameter of the arterioles of the left testis decreased by 32.0%, precapillary arterioles by 36.0%, and the lumen of the hemocapillaries by 24.7%. At the same time, the diameter of the postcapillary venules increased by 44.2% and venules by 47.8%. The density of microvessels in the combined lesion decreased nearly twofold by 49.0%, indicating a critical deterioration of the blood supply and pronounced venous stasis. The combination of diabetes mellitus and burn injury leads to deep destructive restructuring of the microcirculatory bed of the testes.