Association of adiponectin concentration with acute coronary syndrome types in diabetes mellitus: A cross-sectional study

Indah Triayu Irianti; Husaini Umar; Pendrik Tandean; Syakib Bakri; Fabiola Maurren Shinta Adam; Arifin Seweng

Indah Triayu Irianti Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Husaini Umar Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Pendrik Tandean Department of Cardiology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Syakib Bakri Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Fabiola Maurren Shinta Adam Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Arifin Seweng Department of Public Health, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Keywords: adiponectin, acute coronary syndrome, diabetes mellitus

Abstract

Diabetes Mellitus (DM) increases the risk of acute coronary syndrome (ACS). Adiponectin has been popular as a potential indicator for DM and ACS. Hypoadiponectinemia has an important role in the pathogenesis of cardiovascular disease associated with metabolic syndrome. A cross-sectional analytical study with simple random sampling was conducted at Dr. Wahidin Hospital. The study samples were diagnosed with DM and ACS. Data analysis was performed using chi-square tests and odds ratios (ORs). This study involved 88 subjects with DM and ACS who fulfilled the study’s eligibility criteria. The mean adiponectin concentration was 10.27 µg/ml. The subjects with the highest adiponectin concentration quartile (Q4) were those with STEMI (69.6%), and the difference was not statistically significant (chi-square, p>0.05). There is a significant association between dyslipidemia and adiponectin concentration (p<0.05), with the highest adiponectin concentration in the quartile (Q2) at 28.4%. Subjects with hypoadiponectinemia quartile (Q1–Q2) had 11.6 times higher risk of mortality (OR 11.647, 95% CI: 1.407–96.443, p=0.006). There is no significant association between adiponectin concentration and the type of ACS in DM subjects. Dyslipidemia was identified as the predominant risk factor affecting adiponectin concentration. A significant association was found between adiponectin concentration and mortality from acute coronary syndrome in diabetic subjects.