Role of platelet-rich fibrin in wound healing

Abstract

Platelet-rich fibrin (PRF) is a fibrin matrix that can function as a resorbable membrane and trap platelet cytokines, growth factors, and cells. These particles may be discharged from the matrix within a predetermined time frame. Research has demonstrated the use of autologous platelet-rich fibrin in various fields, and it is considered a therapeutic biomaterial. The goal is to review and debate the various approaches to using platelet-rich fibrin as a healing aid in extraoral wound sites. A literature search of review articles, systematic reviews, and studies on platelet-rich fibrin was conducted using PubMed and Google Scholar search engines, focusing on the mesh terms wound healing, growth factors, and regeneration. Hemostasis, graft stabilization, wound sealing, bone regeneration, and wound healing can all be aided by PRF. The fibrin matrix can guide stem cell migration and the healing program more effectively due to its improved organization. Even though PRF is a member of a relatively novel class of platelet concentrates, its considerable cicatricial capacity can be explained by the fibrin molecule’s biologic activity alone. It has recently been demonstrated that there is an excellent opportunity for the PRF to be used as a healing aid in various extraoral treatment contexts, based on encouraging results. Although there was much debate regarding the advantages of first-generation platelet concentrates, second-generation platelet concentrate (L-PRF) appeared to yield better and more consistent outcomes. L-PRF has several benefits, including being autologous, easy to collect, chairside preparation, and straightforward clinical application, thereby avoiding the risks associated with allogeneic products. As such, it appears appropriate for application in both general and specialist practice.