Insight into polyol pathway for diabetic wound care supported by applications of scaffolds
Diabetes foot ulcer (DFU) affects around one-third of diabetic patients, which are mostly caused by peripheral neurovascular disease or peripheral neuropathy. Since diabetic foot ulcers are persistent and difficult to cure, the present study contains a literature review for a better understanding of the neuropathic and ischemic characteristics of diabetes, their control, prevention, and treatment. The researchers discovered that the inhibitors of sorbitol dehydrogenase, AR, Protein Kinase C (PKC) activation, activators of myo-inositol bisphosphatase, nitric oxide synthase and many other enzymes were found to play salient roles in the polyol pathway of diabetic neuropathy. It can be concluded that key elements of the polyol pathway play a vital role in the control, prevention, management, and treatment of diabetic foot ulcers.