Relationship between hsCRP and TSH in patients with subclinical hypothyroidism

Relationship between hsCRP and TSH in patients with subclinical hypothyroidism

  • Anuradha Ganesan Department of Biochemistry, Chettinad hospital and research institute, Kelambakkam, Chengalpattu district, Tamil nadu-603103
  • Santhini Gopalakrishnan Sethulekshmi Department of Biochemistry, Chettinad hospital and research institute, Kelambakkam, Chengalpattu district, Tamil nadu-603103
  • Mahalakshmi R Head of the Department, Department of Biochemistry, Tagore Hospital and Research Institute, Rathinamangalam, Melakottaiyur, Tamil nadu-600127
Keywords: Subclinical hypothyroidism, cardiovascular disease, and inflammatory marker.

Abstract

Background: Subclinical hypothyroidism patients are at high risk of developing cardiovascular disease. Identifying the risk factors
like high sensitivity C-reactive protein (hsCRP) and lipid profile in patients with subclinical hypothyroidism helps in the early diagnosis and treatment of cardiovascular disease (CVD). The mortality and morbidity due to CVD can be reduced and further progression to overt hypothyroidism can be halted. This study aims to assess the levels of inflammatory markers like hsCRP and lipid profile and their relationship with TSH in subclinical hypothyroidism. Material and methods: The study population comprised
300 patients with subclinical hypothyroidism (SCH) and 300 euthyroid. It was an analytical cross-sectional study. The levels of free thyroxine (fT4), and thyroid-stimulating hormone (TSH) in serum samples were measured using the chemiluminescence
immunoassay method. The serum Lipid profile and hsCRP were measured using Seimens autoanalyzer. Low-density lipoprotein (LDL-C) and very low-density lipoprotein (VLDL-C) were calculated using friedewald formula. Results: The observed means of SCH and euthyroid were compared using student’s unpaired t-test to determine if there was a significant difference between the two. The mean levels of TSH, hsCRP, Total cholesterol, Triglycerides, LDL-C, and VLDL-C were found to be highly significant (p<0.0001). The mean levels of fT4, and HDL-C were found to be significant (p<0.05). Pearson’s correlation analysis showed a significant positive correlation between TSH and hsCRP in subclinical hypothyroidism. Conclusion: hsCRP and lipid profile may be used as a marker to predict the underlying inflammatory process that leads to the development of cardiovascular disease in subclinical hypothyroidism. Early diagnosis and treatment will prevent the progression of subclinical hypothyroidism to overt hypothyroidism

Published
2021-12-10
How to Cite
Ganesan, Anuradha, Santhini Sethulekshmi, and Mahalakshmi R. 2021. “Relationship Between HsCRP and TSH in Patients With Subclinical Hypothyroidism”. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 28 (4), 391-94. https://www.rjdnmd.org/index.php/RJDNMD/article/view/1023.