Sirtuin 1 but not Osteocalcin, Correlates with Lipid Accumulation Product, Visceral Adiposity and Atherogenicity Indices in Newly Diagnosed Prediabetes-Metabolic Syndrome Patients

Abstract

Background & aims: Osteocalcin (OCN) and Sirtuin 1 (SIRT1) are intricately involved in metabolic syndrome (MetS) and prediabetes (PreDM) anomalies and derangements. In a heterogeneous pool of nondiabetic and preDM MetS recruits, adiposity, atherogenecity and blood indices, SIRT1 and OCN were to be compared vs. respective parameters in normoglycemic and lean controls. Further testing of putative relationships between indices and markers were examined in 59-MetS study population. Materials & Methods: In this cross-sectional study comparisons and correlations were undertaken for biomarkers, adiposity, atherogenicity and hematological indices in 29 MetS-normoglycemic and 30 newly diagnosed drug naïve MetS-preDM patients versus 29 lean, healthy and normoglycemic controls. ANOVA and Spearman rank correlations were used for statistical comparisons. Results: OCN level (OCN; ng/mL) was significantly higher in normoglycemic MetS vs. both MetS-PreDM and controls (28.13±1.22 and 26.02±3.2 vs. 23.3±3.19, P<0.001 respectively). In contrast, circulating level of SIRT1 (ng/mL) was lower in both normoglycemic and preDM MetS vs. healthy controls (1.42±0.47 and 1.64±0.58 vs. 3.88±0.95; P<0.001 respectively). Except for fasting plasma glucose and A1C; no further intergroup discrepancy could be identified between normoglycemic-MetS and preDM-MetS. Notably, adiposity indices and atherogenecity index of plasma were significantly higher in both MetS (normoglycemic and preDM) groups vs. controls’. LDL-C/HDL-C ratio, visceral adiposity index, and waist/hip ratio were greater only in MetS-preDM vs. controls. In MetS pool (n=59); OCT, but not SIRT1, associated reciprocally with fasting glycemia and A1C, monocyte/lymphocyte ratio but proportionally with HC. Significantly in the same MetS pool; SIRT1 correlated positively with TG, lipid accumulation product, visceral adiposity index and atherogenecity index of plasma. Conclusions: OCN and SIRT1 may reciprocally participate in the development of MetS and preDM; both biomarkers may be putatively surrogate diagnostic/prognostic tools for metabolic anomalies prediction/prevention and pharmacotherapy.